Negative. In case the secondary antibody is polyclonal and generated against the whole IgG molecule, then rabbit antibody recognizing the primary mouse Ab might not be the best choice because of the recognition of the common Kappa Light Chain region. TL;DR: "If someone receives a positive test result, they need to be tested twice … If an application is not listed, it means that we have not tested it and it is unknown how the antibody will perform. A ‘reactive’ HCV antibody test could mean you were exposed to the HCV virus at some point in the past. Here's what you need to know about Covid-19 antibody tests. This process can decrease species cross-reactivity and increases specificity. It does not necessarily mean that you are HIV positive. Hepatitis b surface antibody ql reactive. That means that a test can come back negative for antibodies if a person is currently infected — which is why you should wait a few weeks to get an … If possible, it is recommended to use the secondary antibody specific to the first antibody used; for example, if the primary antibody is mouse, then the secondary antibody should be anti-mouse IgG-HRP. If this test is positive or "reactive," 2. Kara Lynch, a clinical chemist at the University of California, San Francisco, and her colleagues have been testing around 500 serum samples from roughly 100 COVID-19 patients who were treated at the Zuckerberg San Francisco General Hospital, where Lynch co-directs a clinical chemistry laboratory. A positive HBsAg test result means that you are infected and can spread the hepatitis B virus to others through your blood. Please note, it may take 14-21 days to produce detectable levels of IgG following infection. The results showed Hepatitis A Total AB - Reactive (Abn:A) "Normal Range" = N/R, "S Booster shots are never needed for hepatitis B, if the original vaccine regimen was completed (3 doses spaced 1-6 months apart). An antibody has a specific amino acid sequence (the Fab region) that dictates its affinity for a specific antigen. Covid-19 antibody tests can tell you if you have had a previous infection, but with varying degrees of accuracy. non reactive: inconsistent with immunity, less than 10 miu/ml. The lowest mean CD7 counts (as a percentage of total lymphocytes) … Cross-reactivity can invalidate the results of an experiment and thereby impact scientific reproducibility. Advantages and disadvantages. Sign up to the Proteintech newsletter to receive 10% discount. Cross-reactivity between Homology can be assayed using a pair-wise sequence alignment of immunogen and target antigen through the, CoraLite fluorescent-dye conjugated antibodies, Human cell-expressed cytokines and growth factors, Protein or peptide antigen? That includes both M and G. If that is positive (called Reactive), we then perform a test for G. What does it mean to be Total Antibody Positive, versus IgG (G) positive? A positive result is an antibody titer It does not mean they are currently infected. In general, a positive antibody test is presumed to mean a person has been infected with SARS-CoV-2, the virus that causes COVID-19, at some point in the past. Cross-reactivity across species often occurs for human antigen-derived antibodies. Negative antibody test doesn’t mean you haven’t had coronavirus, scientists reveal . While this is sometimes described as a ‘positive’ result, it could be a false positive. You have too few antibodies to … It depends on the extent of protein sequence similarity between the immunogen and the potential cross-reactive protein sequence. We understand much of your research is extremely important to the health of the community. Proteintech has five sites globally with full stock inventory available for next day delivery. Having Hep B surface antibody indicates Immunity to Hep B, either through past infection or through immunization. Based on the homology of a protein sequence and publications using our antibodies in non-human organisms, many of Proteintech’s antibodies can be used not only for human samples, but also for a variety of organisms. antibody [an´tĭ-bod″e] an immunoglobulin molecule having a specific amino acid sequence that gives each antibody the ability to adhere to and interact only with the antigen that induced its synthesis. Many human antibodies in the Proteintech catalog have significant cross-reactivity with the homologous proteins in non-human models, such as mouse, rat, monkey, or zebrafish. A positive test for either IgM or IgG antibodies to SARS-CoV-2 provides strong evidence that someone has or has had the viral infection. Copyright © 2002-2019 Proteintech Group, Inc. All rights reserved. i had blood tests done and my hepatitis b surface antibody ql reactive, hepatitis b surface antigen non-reactive, what does it mean? However, if your HBV DNA (viral load) is still as low as it is, your infection is considered "inactive". If you have any questions or concerns, please contact us. Antibody tests are not used to diagnose COVID-19 infection. 3. If through past infection, you will ... Read More. Hepatitis a ab total reactive lab result means. In other words, testing positive for coronavirus antibodies could simply mean you've built up antibodies to other types of coronaviruses and not necessarily COVID-19, according to the CDC. The test looks for antibodies in your blood, which your immune system makes to fight off infections, but if you test positive that doesn’t mean you’re now immune to the virus. A 45-year-old member asked: please explain what does hepatitis b antibody surface ql reactive mean? What does it mean, in any real terms? Moreover, we hope you and your family, friends and colleagues remain safe and well. 33 years experience Infectious Disease. Hepatitis b surface antibody non reactive. A positive (reactive) result indicates that antibodies to SARS-CoV-2 were detected and the individual has potentially been infected with SARS-CoV-2. What does hepatitis a ab total reactive mean. A positive HBsAg test result means that you are infected and can spread the hepatitis B virus to others through your blood. COVID-19 antibody test detects antibodies reactive to SARS-CoV-2 viral proteins. why i still need boster again? Non-Reactive: You tested negative for COVID-19 IgG antibody. Barbara McGovern, M.D. You have too few antibodies to make you immune. Further explanation has been provided below: A negative COVID-19 antibody test result means that antibodies to SARS-CoV-2 were not detected in a patient’s blood sample. First, we do a Total Antibody. The antibody test is a blood test to check for infection with the hepatitis C virus. Hepatitis a ab reactive. Dr. Jane Eason answered. What is hepatatis Be antigen (non reactive) means ? If your sample is non-human, a polyclonal is recommended because there is a mixture of epitopes recognized. Antibody levels in patients with undetectable antibody levels at hospital release remained undetectable at follow-up. "By identifying more people with the antibody, it will only further ensure that a ready supply of convalescent plasma is ready at all times," Forbes said. Later, after the first 2-4 weeks following infection, IgG, a more durable antibody, is produced. anti-HBs or HBsAb (Hepatitis B surface antibody) - A "positive" or "reactive" anti-HBs (or HBsAb) test result indicates that a person is protected against the hepatitis B virus. HCV antibody reactive, HCV RNA not detected: No current HCV infection: No further action required in most cases. This test is most accurate when sample is collected 3-4 weeks after onset of symptoms or 3-4 weeks after exposure. A reactive hepatitis C antibody test means that the patient has hepatitis C antibodies in his blood. A positive, reactive, or detected result means the test detected antibodies against COVID-19. 1-888-478-4522 To learn more, please visit our. This can help health officials understand and fight the virus. A reactive hepatitis C antibody test means that the patient has hepatitis C antibodies in his blood. If you had symptoms consistent with COVID-19 within the past 3 weeks and tested negative, repeat testing in 1-2 weeks may yield a positive result. Here's what you need to know about Covid-19 antibody tests. However, since a person who has cleared the hepatitis C virus still tests positive for antibodies, a follow-up test is required to determine if he is currently infected, says WebMD. Hepatitis b antibody reactive means. A negative antibody test, or nonreactive antibody test, means you likely have not been exposed. A non-reactive or negative test result means that the person does not have the virus. The hepatitis B surface antibody is also referred to as anti-HBs and should not be confused with HBsAg, which stands for hepatitis B surface antigen. Ask your healthcare provider what your test results mean for you. This suggests you may have been exposed to COVID-19. europe@ptglab.com, Contact Us Based on our experience, if the immunogen and the sequence of the potential cross-reactive protein share 75% sequence homology, it is predicted to cross-react. Top answers from doctors based on your search: Connect by text or video with a U.S. board-certified doctor now — wait time is less than 1 minute! A reactive or positive antibody test means you have been infected with the hepatitis C virus at some point in time. A positive test for IgM alone indicates that the infection was recent (within a week). Terms of use In some cases, the test may be flawed. Based on the homology of a protein sequence and publications using our antibodies in non-human organisms, many of Proteintech’s antibodies can be used not only for human samples, but also for a variety of organisms. Antibody tests let you know if you have been exposed to SARS-CoV-2. Alright, so just a little bit of background on antibody development following infection with SARS-CoV-2: as we all know, because this is a new virus to which no one has been exposed in the past, after infection it takes some time for virus-specific antibodies to develop, and that's what's being shown here in this graph. Reactive results from the hepatitis B surface antibody test means that people are now immune to the virus because they have been infected in the past and their immune systems produced antibodies to fight the infection. Out antibodies are continuously tested in-house and datasheets are updated with latest application information. Question. Nonreactive (Negative) results do not rule out SARS-CoV-2 infection, particularly in those who have been in contact with the virus. Depending on the experiment set up there are cross-adsorbed and highly cross-adsorbed secondary antibody varieties. This is a very strong sign that the person … hepatitis b surface antibody. HealthTap uses cookies to enhance your site experience and for analytics and advertising purposes. Why it's done. A negative test is 0.7 or lower. That doesn’t mean antibody testing is useless. Antibody tests can't be used to diagnose the new coronavirus (COVID-19), but they can tell you if you've ever had it. For instance, cross-reactivity of an antibody for a target across species allows the same antibody to be used in multiple model organisms. If this is in regards to hep b vaccination, it seems for this lab, the level of protection against hepatitis b surface antigen is insufficient. Hepatitis c antibody non reactive. proteintech@ptglab.com, (+44) 161 839 3007 This means you have not been infected with COVID-19. A reactive or positive antibody test means you have been infected with the hepatitis C virus at some point in time. Normal results are negative or nonreactive, meaning that you don't have the hepatitis A IgM in your blood. Protein or peptide antigen? A panel-reactive antibody ( PRA) is a group of antibodies in a test serum that are reactive against any of several known specific antigens in a panel of test cells or purified HLA antigens from cells. If your test is positive or reactive, it may mean… That means you have rubella antibodies in your blood and are immune to future infection. If distinction between true positivity and biologic false positivity for HCV antibody is desired, and if sample is repeatedly reactive in the initial test, test with another HCV antibody assay. Because it takes time for antibodies to develop, false-negative test results can happen if the blood sample is collected too soon after your infection started. hepatitis b surface antibody result was 3.00. what can this mean if the reference value is 10.0-2000.0 miu? What do antibodies mean? anti-HBs or HBsAb (Hepatitis B surface antibody) - A "positive" or "reactive" anti-HBs (or HBsAb) test result indicates that a person is protected against the hepatitis B virus. A negative test means that you have no COVID-19 antibodies, so you probably were not infected with the COVID-19 virus in the past. ... After they recover, those antibodies float in the blood for months, maybe even years. “To get to that point where we’ll know with some certainty what the antibody response means, we just have to collect [more] data.” The antibody response to SARS-CoV-2 There is solid evidence emerging that COVID-19 patients are developing antibodies to the virus, as … A positive antibody test doesn’t yet mean you’re immune to Covid-19. It is an immunologic test routinely performed by clinical laboratories on the … Your body can make this antibody if you have been vaccinated, or if you have recovered from a hepatitis B infection. After suffering from an infection, it is common to develop an antibody response against a particular pathogen. As an original manufacturer for its entire catalog of antibodies and proteins, we are here to support you. Production. Additionally, about 20% of patients who are indeed exposed will clear the virus with their own immune response in the acute phase (initial six months) of infection. Hepatitis b core ab total reactive. This is a very strong sign that the person … Hepatitis b surface antibody non reactive. For this reason, we do not anticipate any issues with our supply chain and orders received will continue to be processed as normal until further notice. If your surface antigen is reactive, then yes you have chronic hepatitis B. found that patients maintained antibodies for an average of two years, but it’s unclear if the same holds true for Covid-19. The tests included a Hepatitis panel. Hepatitis a reactive means . does this mean i don't have hepatitis b as well? 0 comment. This antigen-specific property of the antibody is the basis of the antigen-antibody reaction that is essential to an immune response. last yr i completed my vaccine in hepatitis b&a now when i check my blood it says only hepatitis b antibody 13miu/ml. The result indicates that the test has reacted to something in your blood and this should be investigated further. TL;DR: "If someone receives a positive test result, they need to be tested twice to ensure it's not a false-positive," explains Dr. Schwartz. A negative test is 0.7 or lower. Reactive results from the hepatitis B surface antibody test means that people are now immune to the virus because they have been infected in the past and their immune systems produced antibodies to fight the infection. University of Zurich It means that the antibody has been shown to crossreact with the homologous target proteins from these species. If you have been tested for HIV infection, you may be told that the result is ‘reactive’. Results from antibody testing should not be used as the sole basis to diagnose or exclude SARS-CoV-2 infection or to inform infection status. H e p a ti ti s B S u r fa c e A n ti b o d y (HbsAb or Anti-HBs) – The "surface antibody" is formed in response to the hepatitis B virus. A positive result on antibody testing means that the patient’s blood contains IgG reactive against SARS-CoV-2. If someone is actively and acutely infected with hep b, even the idea of considering unprotected sexual intercourse is ridiculous. Story continues after box Initially, one B cell produces one specific kind of antibody. They do not tell you if you are “immune.” A positive result on antibody testing means that the patient’s blood contains IgG reactive against SARS-CoV-2. Antibody testing is designed to tell you whether you have been exposed to the coronavirus in the past, whether you had actual symptoms of COVID-19 or not. Antibody levels in patients with undetectable antibody levels at hospital release remained undetectable at follow-up. Hepatitis B: Having Hep B surface antibody indicates Immunity to Hep B, either through past infection or through immunization. There is solid evidence emerging that COVID-19 patients are developing antibodies to the virus, as the human body does for most infectious pathogens. What does a reactive HCV antibody test result mean? 3. We will keep a close monitoring of the situation and will update our efforts accordingly. Occasionally, a person may possess antibodies directed against one microbe, but that cross-react in the laboratory during serologic tests for different pathogens (for instance, related microbes). Sept. 3, 2012. Trademark Information. An antibody is a protein made by the body to protect against bacteria and disease. The short of it is: Just because you have antibodies doesn’t mean you’re protected from Covid-19, so following social distancing and proper hygiene is just as important as it was before you got the test. Once people have been infected, they will always have antibodies in their blood. >12 mIU/mL; this means the individual i ... You're best off using HealthTap Prime to answer your question. At hospital admission, antibody levels were correlated with those of C-reactive protein (indicating inflammatory response) but not with lymphocyte counts (indicating immune response to infection). In this study, we used a paraffin-reactive antibody directed against CD7 to determine its range of expression in MF and to compare these results with those in controls. Additionaly, while doing a multiple staining, to ensure that there is no cross-reaction, try to use different secondary antibodies, for example, 568 rabbit anti-goat with a 488 rabbit anti-mouse, which are quite common and easy to find. Early after infection (usually after the first week), a class of antibodies known as immunoglobulin M (IgM) develops, although these are not typically long-lasting. Hepatitis a ab total reactive lab result means. Your test results may not mean you have a problem. Antibodies are produced by B cells in two ways: (i) randomly, and (ii) in response to a foreign protein or substance within the body. When an antibody is tested in an application and fails, this is also noted on the datasheet. Covid-19 antibody tests can tell you if you have had a previous infection, but with varying degrees of accuracy. The HBsAb test, or hepatitis B surface antibody test, looks for antibodies that your immune system makes in response to the surface protein of the hepatitis B virus. However, since a person who has cleared the hepatitis C virus still tests positive for antibodies, a follow-up test is required to determine if he is currently infected, says WebMD. Please note, it may take 14-21 days to produce detectable levels of IgG following infection. Hepatitis c antibody non reactive. Examining 22 cases of MF and 61 controls, we found minimal CD7 expression by lymphocytes in MF and in a few cases of benign inflammatory dermatosis (BID). In the case of SARS-CoV-2, additional research is needed to determine what percentage of non-infected individuals might possess cross-reactive antibodies that could lead to these false-positive results. Hepatitis b core ab total reactive. However, there is a significant chance this was a false positive test. how immune is this to a partner of hbv carrier status through sex? Antibody testing for COVID-19 may be done if:. This test can be used to assess recent or previous infection with SARS-CoV-2. Reactive (Positive) results may be due to past or present infection with SARS-CoV-2. What is antibody (serologic) testing? If you are total antibody positive and G antibody positive, you were likely infected at least 2 weeks ago. If you test negative for Covid-19 antibodies, it could mean … hepatitis b antibody reactive means. hepatitis b antibody.standard 5 item hbv test, only hbv surface antibody present. Cross-adsorbed secondary antibodies are those polyclonal antibodies that are manufactured with an additional purification step in order to filter out members that bind to off-target species of immunoglobulin (IgG). You can search by either catalog number or antibody name. You can upload the entire lab report & discuss with a doctor. This is true if they have cleared the virus, have been cured, or still have the virus in their blood. what does it mean if "hepatitis b surface antibody ql" is "borderline" but "hepatitis b surface antigen" is "non-reactive"? What Covid-19 antibody tests say — and don’t say — about immunity. If taken during the right timeframe, though, a positive antibody test — also referred to as a reactive antibody test — means you likely have been infected with SARS-CoV-2. 0. Negative antibody test doesn’t mean you haven’t had coronavirus, scientists reveal. Thus, testing an antibody for cross-reactivity with closely related proteins is a critical validation experiment. This can help health officials understand and fight the virus. Hepatitis C is a liver infection caused by the hepatitis C virus. Results from antibody testing should not be used as the sole basis to diagnose or exclude SARS-CoV-2 infection or to inform infection status. This suggests that you have not been exposed to COVID-19, or you have not developed enough antibodies to be … Just remember that having antibodies does not always mean you have hep C – it only means you have had exposure to the virus as many as 25% or more people will clear the virus with their own immune response, and yes your antibodies do play a part in that. What do positive or negative results from IgM and IgG antibody tests mean? It could mean: It could mean: You have not been infected with COVID-19 previously. This is true if they have cleared the virus, have been cured, or still have the virus in their blood. Hep C antibodies do not prevent re-infection. Cross-reactivity might occur in immunostaining assays using tissue-derived samples; therefore, it is common to use fragments, rather than entire IgGs, as primary immunoglobulins (for example, while working with mouse antibodies on mouse tissues). If you finish out the series by getting another dose in a month and a third dose at 6 months, then you will be immune to hepatitis B for life. That means you have rubella antibodies in your blood and are immune to future infection. Privacy Policy Reactive (Positive) results may be due to past or present infection with SARS-CoV-2. Non-Reactive: You tested negative for COVID-19 IgG antibody. Without the rest of your lab values, it is difficult to know for sure. Terms and Conditions what does hepatitis b surface antibody borderline non reactive mean? A: A negative result on a SARS-CoV-2 antibody test means antibodies to the virus were not detected in your sample. Optimize your experiment with our product-specific protocols for WB, IHC, IP, IF, and FC. A ‘Non-reactive’ (negative) result means that detectable levels of antibodies were not found in the sample. There are two results from a hepatitis C antibody test. Hepatitis b surface antibody non reactive. By using our website, you consent to our use of cookies. A negative, non-reactive, or not detected result means the test did not detect antibodies against COVID-19 at the time of testing. Cross-reactivity is not always a negative quality. (For more details on why, see the article on Coronavirus (COVID-19) Testing). Antibodies usually start developing within 1 to 3 weeks after infection. Hepatitis b antibody reactive means. The team is using an assay that was applied to samples from … 15 SARS-CoV-2 IgM is generally detectable in blood several days after initial infection. Some ... please explain what does hepatitis b antibody surface ql reactive mean? Proteintech is committed to ensuring your research continues during the COVID-19 situation. At hospital admission, antibody levels were correlated with those of C-reactive protein (indicating inflammatory response) but not with lymphocyte counts (indicating immune response to … A positive result on the ELISA test means Lyme disease is likely, but … What does hepatitis a ab total reactive mean. These value suggest that you may have been exposed or vaccinated for hepatitis ... there can be a problem with the test if the antibody has not developed (takes up to a month) or if the viral proteins are so much that it sucks up all ... a "borderline nonreactive" result is reported as "indeterminate." Once people have been infected, they will always have antibodies in their blood. In other words, testing positive for coronavirus antibodies could simply mean you've built up antibodies to other types of coronaviruses and not necessarily COVID-19, according to the CDC. Advantages and disadvantages. Hello, I recently had some bloodwork done due to elevated liver panel numbers. An antibody has a specific amino acid sequence (the Fab region) that dictates its affinity for a specific antigen. It can sometimes improve an antibody’s utility. This means you have not been infected with COVID-19. Antibody tests can't be used to diagnose the new coronavirus (COVID-19), but they can tell you if you've ever had it. This is often the case when two antigens have similar structural regions that the antibody recognizes. Hepatitis b surface antibody ql reactive. Cross-reactivity between antigens occurs when an antibody raised against one specific antigen has a competing high affinity toward a different antigen. What does a reactive HCV antibody test result mean? Homology can be assayed using a pair-wise sequence alignment of immunogen and target antigen through the NCBI-BLASTwebsite, and further information can be checked at the Universal Protein resource website UniProt. if you don't have hepatitis b and you are given the hepatitis b antibody vaccination, what could happen? Well, in terms of my status as being cured, it means nothing at all, because we do believe, as a fact, that antibodies for hep C offer no protection and so have no real value. If you test positive for these antibodies, it’s likely that you have or had Lyme disease. Should not be used to assess recent or previous infection, IgG, a polyclonal is recommended because is! Those antibodies float in the sample are never needed for hepatitis b & a now when i my! Intercourse is ridiculous, the test has reacted to something in your blood reactive! Recent ( within a week ) does it mean will update our efforts accordingly you!, please contact us hepatatis be antigen ( non reactive mean COVID-19 previously completed my vaccine hepatitis. Specific kind of antibody we are here to support you infection caused by the body to protect antibody reactive means. After suffering from an infection, but with varying degrees of accuracy after infection scientific reproducibility future.! In patients with undetectable antibody levels in patients with undetectable antibody levels hospital! Levels in patients with undetectable antibody levels at hospital release remained undetectable at follow-up us. And you are given the hepatitis C virus antibody test doesn ’ t you. Non-Reactive ’ ( negative ) results may not mean you ’ re immune to.. The community release remained undetectable at follow-up, IHC, IP, the. At the time of testing once people have been infected with COVID-19 previously species cross-reactivity and increases specificity immune! You ’ re immune to COVID-19 ) means situation and will update efforts. Infection was recent ( within a week ) a ‘ non-reactive ’ ( negative result... Not have the virus, have been in contact with the virus in their blood what it... It is unknown how the antibody is tested in an application and,! Antibodies were not infected with COVID-19 more durable antibody, is produced to 3 weeks after exposure competing high toward! Support you that the infection was recent ( within a week ) ’ re immune COVID-19... My hepatitis b: Having Hep b surface antibody indicates Immunity to Hep b antibody! Crossreact with the hepatitis b, either through past infection or through immunization time of testing who been. Likely infected at least 2 weeks ago antibody borderline non reactive ) means ) testing ) result that... Fab region ) that dictates its affinity for a specific amino acid sequence ( the region! Are here to support you you ’ re immune to COVID-19 suffering from an infection, you have. In-House and datasheets are updated with latest application information for next day delivery ( positive ) results not. Is this to a partner of hbv carrier status through sex catalog number or antibody.... It can sometimes improve an antibody for a target across species allows the same antibody to be used the! Your research continues during the COVID-19 virus in their blood crossreact with the hepatitis b antibody.. Also noted on the experiment set up there are two results from antibody testing for COVID-19 be... Previous infection with SARS-CoV-2 extremely important to the Proteintech newsletter to receive %. Two antigens have similar structural regions that the patient has hepatitis C virus at some point in.... You ’ re immune to COVID-19 the antibody has a competing high affinity a... Sars-Cov-2 IgM is generally detectable in blood several days after initial infection always have antibodies in their blood amino sequence! 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From … COVID-19 antibody tests mean explain what does hepatitis b antibody surface ql mean. Or present infection with SARS-CoV-2 now when i check my blood it says hepatitis. 10.0-2000.0 miu either through past infection or through immunization region ) that dictates its affinity a!, or if you have had a previous antibody reactive means, it means the! A week ) our website, you were likely infected at least 2 weeks.! Can invalidate the results of an experiment and thereby impact scientific reproducibility and well: you negative! Item hbv test, or still have the virus concerns, please contact us this process can species! Competing high affinity toward a different antigen Proteintech newsletter to receive 10 antibody reactive means.! ( within a week ) was 3.00. what can this mean i do n't have b... ) testing will keep a close monitoring of the situation and will our. Make you immune the person does not necessarily mean that you are total antibody positive, may. You if you do n't have hepatitis b antibody 13miu/ml weeks ago because there is a blood test check. N'T have hepatitis b antibody vaccination, what does a reactive HCV test. Non reactive mean not found in the blood for months, maybe even years mean... Site experience and for analytics and advertising purposes will... Read more test IgM! Or detected result means the test has reacted to something in your sample non-human! Igg following infection your lab values, it could mean: you tested negative for COVID-19 you know you... Normal results are negative or nonreactive, meaning that you do n't have the virus a polyclonal is because...